Based on the severity of the symptoms, a healthcare provider may recommend treatment of specific organ systems affected by infectious mononucleosis.īecause your spleen may become enlarged as a result of infectious mononucleosis, you should avoid contact sports until you fully recover. If you have infectious mononucleosis, you should not take penicillin antibiotics like ampicillin or amoxicillin. taking over-the-counter medications for pain and fever.You can help relieve symptoms of infectious mononucleosis by. You can help protect yourself by not kissing or sharing drinks, food, or personal items, like toothbrushes, with people who have infectious mononucleosis. There is no vaccine to protect against infectious mononucleosis. Other infections that can cause infectious mononucleosis:
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